PLK2 Single Nucleotide Variant in Gastric Cancer Patients Affects miR-23b-5p Binding.

ABSTRACT:

Purpose

Chromosomal instability is a hallmark of gastric cancer (GC). It can be driven by single nucleotide variants (SNVs) in cell cycle genes. We investigated the associations between SNVs in candidate genes, PLK2, PLK3, and ATM, and GC risk and clinicopathological features.

Materials and methods

The genotyping study included 542 patients with GC and healthy controls. Generalized linear models were used for the risk and clinicopathological association analyses. Survival analysis was performed using the Kaplan-Meier method. The binding of candidate miRs was analyzed using a luciferase reporter assay.

Results

The PLK2 C_rs15009-C_rs963615 haplotype was under-represented in the GC group compared to that in t

SUBMITTER: Dominkus PP 

PROVIDER: S-EPMC9633926 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature