Real-World Usage of Sacubitril/Valsartan in Korea: A Multi-Center, Retrospective Study.

ABSTRACT:

Background and objectives

Differences in drug prescriptions exist between clinical trials and real-world practice. We evaluated the real-world treatment patterns of sacubitril/valsartan in Korean patients with heart failure (HF).

Methods

In this retrospective, multicenter cohort study, 600 patients with HF with reduced left-ventricular ejection fraction (LVEF <40%) with ≥1 sacubitril/valsartan prescription were identified by reviewing patient-level medical records at six academic tertiary hospitals in Korea between February 2017 and April 2019.

Results

At baseline, 59.2%, 28.3%, 4.8%, and 7.7% of the patients received low (50 mg bid), moderate (100 mg bid), target (200 mg bid), and unconventional dose of sacubitril/valsartan, respectively. Patients with low and modera

SUBMITTER: Park JJ 

PROVIDER: S-EPMC9634027 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature