Prognostication of early-onset endometrioid endometrial cancer based on genome-wide DNA methylation profiles.

ABSTRACT:

Objective

The aim of this study was to establish criteria that would indicate whether fertility preservation therapy would likely be safe for patients aged 40 years or less with endometrioid endometrial cancer based on their DNA methylation profile.

Methods

Forty-nine fresh-frozen tissue samples from patients with endometrial cancer from an initial cohort and 31 formalin-fixed paraffin-embedded tissue samples from a second cohort were subjected to genome-wide DNA methylation analysis using the Infinium MethylationEPIC BeadChip.

Results

Epigenomic clustering of early-onset endometrial cancer was correlated with the widely used recurrence risk classification. Genes showing differences in DNA methylation levels between the low-recurrence-risk category and intermediate- a

SUBMITTER: Hirano T 

PROVIDER: S-EPMC9634101 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature