In vitro activities of licochalcone A against planktonic cells and biofilm of Enterococcus faecalis.

ABSTRACT: This study aims to evaluate the in vitro antibacterial and anti-biofilm activities of licochalcone A on Enterococcus faecalis and to investigate the possible target genes of licochalcone A in E. faecalis. This study found that licochalcone A had antibacterial activities against E. faecalis, with the MIC₅₀ and MIC₉₀ were 25 μM. Licochalcone A (at 4 × MIC) indicated a rapid bactericidal effect on E. faecalis planktonic cells, and killed more E. faecalis planktonic cells (at least 3-log₁₀ cfu/ml) than vancomycin, linezolid, or ampicillin at the 2, 4, and 6 h of the time-killing test. Licochalcone A (at 10 × MIC) significantly reduced the production of E. faecalis persister cells (at least 2-log₁₀ cfu/

SUBMITTER: Liu X 

PROVIDER: S-EPMC9634178 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature