Comparison of analytical performances between clot waveform analysis and FibWave in edoxaban-treated patients and healthy controls.

ABSTRACT:

Introduction

The activated partial thromboplastin time (aPTT) and the prothrombin time (PT) are widely available coagulation parameters which are however poor predictors of the anticoagulant effect of direct oral anticoagulants (DOACs). Some coagulometers use the clot waveform analysis (CWA) to assess the clotting time but mainly based on a unique parameter. The improvement of these methodologies and the evaluation of the other waveform parameters may increase the sensitivity to DOACs.

Objectives

To assess the performance of an improved clot waveform an method (i.e. FibWave) to detect the impact of edoxaban on the coagulation and the fibrinolytic systems.

Methods

Seventy-one samples from patients treated with edoxaban collected at minimum concentration (C_TROUGH</

SUBMITTER: Evrard J 

PROVIDER: S-EPMC9634266 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature