Single-cell transcriptomics reveals variable trajectories of CSPCs in the progression of osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is characterised by cartilage destruction; however, there are no specific drugs available for its treatment. Cartilage-derived stem/progenitor cells (CSPCs) are multipotent cells that play an essential role in cartilage renewal and may provide critical insights into the medical needs for OA treatment. However, alterations in cell function and fate of CSPCs during OA progression have seldom been analysed, especially at the single-cell level. Additionally, it has been reported that CSPCs can migrate to the cartilage injury area, although the mechanism of migration remains elusive. Thus, understanding the changing patterns of CSPCs in the pathological process of OA is important in the effort to develop stem cell therapy for OA. Here, we downloaded single-cell transcriptomi

SUBMITTER: Qi L 

PROVIDER: S-EPMC9634280 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature