Drug repurposing in cardiovascular inflammation: Successes, failures, and future opportunities.

ABSTRACT: Drug repurposing is an attractive, pragmatic approach to drug discovery that has yielded success across medical fields over the years. The use of existing medicines for novel indications enables dramatically reduced development costs and timescales compared with de novo drug discovery and is therefore a promising strategy in cardiovascular disease, where new drug approvals lag significantly behind that of other fields. Extensive evidence from pre-clinical and clinical studies show that chronic inflammation is a driver of pathology in cardiovascular disease, and many efforts have been made to target cardiovascular inflammation therapeutically. This approach has been met with significant challenges however, namely off-target effects associated with broad-spectrum immunosuppression, pa

SUBMITTER: Chaffey L 

PROVIDER: S-EPMC9634418 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature