Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation.

ABSTRACT: Emerging evidence associates translation factors and regulators to tumorigenesis. However, our understanding of translational changes in cancer resistance is still limited. Here, we generated an enzalutamide-resistant prostate cancer (PCa) model, which recapitulated key features of clinical enzalutamide-resistant PCa. Using this model and poly(ribo)some profiling, we investigated global translation changes that occur during acquisition of PCa resistance. We found that enzalutamide-resistant cells exhibit an overall decrease in mRNA translation with a specific deregulation in the abundance of proteins involved in mitochondrial processes and in translational regulation. However, several mRNAs escape this translational downregulation and are nonetheless bound to heavy polysomes in enzalutamid

SUBMITTER: Lelong EIJ 

PROVIDER: S-EPMC9634437 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature