Case-fatality rate of major bleeding events in patients on dual antiplatelet therapy after percutaneous coronary intervention: A systematic review and meta-analysis.

ABSTRACT:

Background

Assessment of the case-fatality rate (CFR) of major bleeding on dual antiplatelet therapy (DAPT) may improve balancing risks and benefits of different durations of DAPT following percutaneous coronary intervention (PCI).

Objectives

To determine the CFR of major bleeding in patients on DAPT after PCI and to compare rates among different durations of DAPT.

Methods

Medline, Embase, and CENTRAL were searched from inception to August 2021 for randomized trials that reported fatal bleeding among patients who were randomized to ≥1 month of DAPT following PCI. Summary estimates for CFRs of major bleeding were calculated using the random-effects inverse-variance method. Statistical heterogeneity was evaluated using the I ² statistic.

Results

SUBMITTER: Tritschler T 

PROVIDER: S-EPMC9634492 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature