Interplay of Immunosuppression and Immunotherapy Among Patients With Cancer and COVID-19.

ABSTRACT:

Importance

Cytokine storm due to COVID-19 can cause high morbidity and mortality and may be more common in patients with cancer treated with immunotherapy (IO) due to immune system activation.

Objective

To determine the association of baseline immunosuppression and/or IO-based therapies with COVID-19 severity and cytokine storm in patients with cancer.

Design, setting, and participants

This registry-based retrospective cohort study included 12 046 patients reported to the COVID-19 and Cancer Consortium (CCC19) registry from March 2020 to May 2022. The CCC19 registry is a centralized international multi-institutional registry of patients with COVID-19 with a current or past diagnosis of cancer. Records analyzed included patients with active or previous cancer who had a

SUBMITTER: Bakouny Z 

PROVIDER: S-EPMC9634600 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature