Dataset Information

The mental health associations of vitiligo: UK population-based cohort study.

ABSTRACT:

Background

Vitiligo is an acquired, autoimmune depigmenting skin disorder that may affect psychological well-being.

Aims

To determine the risk and impact of psychological comorbidity in people with new-onset vitiligo.

Method

We conducted a retrospective observational study, using UK general practice data (2004-2020). Adults diagnosed with vitiligo (n = 7224) were matched 1:4 with controls (n = 28 880). Associations within 2 years of diagnosis were assessed for psychological conditions: recurrent depressive disorder (RDD), depressive episodes, non-phobia-related anxiety disorder, social phobia, adjustment disorder, substance misuse, self-harm and suicide attempts. Healthcare utilisation, time off work and unemployment within 1 year were compared in those with and without a mental health condition at vitiligo diagnosis.

Results

At diagnosis, people with vitiligo had a similar prevalence of mental health conditions as controls, except for anxiety disorder (cases 7.9%, controls 7.0%; P = 0.014). Incident RDD and anxiety disorder were more common in people with vitiligo (RDD: adjusted hazard ratio (aHR) 1.25, 95% CI 1.01-1.55; anxiety disorder: aHR 1.23, 95% CI 1.00-1.51). Risk was highest in Black and minority ethnic individuals (RDD: aHR 1.72, 95% CI 1.06-2.79; depressive episodes: aHR 1.56, 95% CI 1.03-2.37). No association was found with other mental health conditions. People with vitiligo and psychological comorbidity had more primary care encounters, more time off workand higher unemployment.

Conclusions

People with vitiligo have a higher incidence of RDD and anxiety disorder than controls, and this risk increase may be greatest in Black and minority ethnic populations.

SUBMITTER: Thompson AR

PROVIDER: S-EPMC9634603 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

The mental health associations of vitiligo: UK population-based cohort study.

Thompson Andrew R AR Eleftheriadou Viktoria V Nesnas John J

BJPsych open 20221021 6

<h4>Background</h4>Vitiligo is an acquired, autoimmune depigmenting skin disorder that may affect psychological well-being.<h4>Aims</h4>To determine the risk and impact of psychological comorbidity in people with new-onset vitiligo.<h4>Method</h4>We conducted a retrospective observational study, using UK general practice data (2004-2020). Adults diagnosed with vitiligo (<i>n</i> = 7224) were matched 1:4 with controls (<i>n</i> = 28 880). Associations within 2 years of diagnosis were assessed for ...[more]

PMID: 36268886

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Dataset Information

The mental health associations of vitiligo: UK population-based cohort study.

Background

Aims

Method

Results

Conclusions

Publications

The mental health associations of vitiligo: UK population-based cohort study.

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