Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects.

ABSTRACT:

Background and aims

Efficacy evaluations with preclinical magnetic resonance imaging (MRI) are uncommon, but MRI in the preclinical phase of drug development provides information that is useful for longitudinal monitoring. The study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide (TAA)-induced model of liver injury in rats. Correlation analysis was conducted to assess compare the monitoring of liver function by MRI and biomarkers.

Methods

TAA was injected three times a week for 8 weeks to generate a disease model (TAA group). In the TAA and silymarin-treated (TAA-SY) groups, silymarin was administered three times weekly from week 4. MR images were acquired at 0, 2, 4, 6, and 8 weeks in the control, TAA, a

SUBMITTER: Chae YJ 

PROVIDER: S-EPMC9634766 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature