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Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate.

ABSTRACT: A method to obtain single crystals of the opioid antagonist naloxone in the free base form is facilitated using mechanochemistry. The application of mechanochemistry reduces the number of steps and makes single crystals readily available from solution compared to using an approach based exclusively on solution or the reported method based on sublimation. The X-ray structure confirms the structure determined using powder diffraction and provides details of hydrogen bonding.

SUBMITTER: Ortiz-de Leon C

PROVIDER: S-EPMC9634803 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate.

Ortiz-de León Celymar C Hartwick Christopher J CJ Stuedemann Clara A CA Brogden Nicole K NK MacGillivray Leonard R LR

Crystal growth & design 20221017 11

A method to obtain single crystals of the opioid antagonist naloxone in the free base form is facilitated using mechanochemistry. The application of mechanochemistry reduces the number of steps and makes single crystals readily available from solution compared to using an approach based exclusively on solution or the reported method based on sublimation. The X-ray structure confirms the structure determined using powder diffraction and provides details of hydrogen bonding. ...[more]

PMID: 36345388

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