Metagenomic and metabolomic analyses show correlations between intestinal microbiome diversity and microbiome metabolites in ob/ob and ApoE^-/- mice.

ABSTRACT: Obesity and atherosclerosis are the most prevalent metabolic diseases. ApoE^-/- and ob/ob mice are widely used as models to study the pathogenesis of these diseases. However, how gut microbes, gut bacteriophages, and metabolites change in these two disease models is unclear. Here, we used wild-type C57BL/6J (Wt) mice as normal controls to analyze the intestinal archaea, bacteria, bacteriophages, and microbial metabolites of ob/ob and ApoE^-/- mice through metagenomics and metabolomics. Analysis of the intestinal archaea showed that the abundances of Methanobrevibacter and Halolamina were significantly increased and decreased, respectively, in the ob/ob group compared with those in the Wt and ApoE^-/- groups (p < 0.05). Compared with those

SUBMITTER: Dong S 

PROVIDER: S-EPMC9634818 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature