Cell segregation via differential collision modes between heterotypic cell populations.

ABSTRACT: In tissue development and regeneration, the establishment of sharp boundaries between heterotypic cells is essential for the differentiation of tissue functions. During the dynamic rearrangements of constituent cells that result from cell division and collective migration, the segregation boundary encounters various challenges. Several studies have suggested that cortical actomyosin structures play a crucial role in the maintenance of the boundary interface of segregated cell populations, implicating actin-mediated stresses. Examining physical cellular properties such as motility, traction, and intercellular stress, we investigated the formation and maintenance of the stable segregation between epithelial and mesenchymal cell populations devoid of heterotypic adhesions. At the contact boun

SUBMITTER: Lucia SE 

PROVIDER: S-EPMC9634969 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature