Pharmaceutical Agents for Contractile-Metabolic Dysfunction After Volumetric Muscle Loss.

ABSTRACT: Volumetric muscle loss (VML) injuries represent a majority of military service member casualties and are common in civilian populations following blunt and/or penetrating traumas. Characterized as a skeletal muscle injury with permanent functional impairments, there is currently no standard for rehabilitation, leading to lifelong disability. Toward developing rehabilitative strategies, previous research demonstrates that the remaining muscle after a VML injury lacks similar levels of plasticity or adaptability as healthy, uninjured skeletal muscle. This may be due, in part, to impaired innervation and vascularization of the remaining muscle, as well as disrupted molecular signaling cascades commonly associated with muscle adaptation. The primary objective of this study was to assess the ab

SUBMITTER: McFaline-Figueroa J 

PROVIDER: S-EPMC9634984 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature