A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.

ABSTRACT: The human brain vasculature is of great medical importance: its dysfunction causes disability and death¹, and the specialized structure it forms-the blood-brain barrier-impedes the treatment of nearly all brain disorders^2,3. Yet so far, we have no molecular map of the human brain vasculature. Here we develop vessel isolation and nuclei extraction for sequencing (VINE-seq) to profile the major vascular and perivascular cell types of the human brain through 143,793 single-nucleus transcriptomes from 25 hippocampus and cortex samples of 9 individuals with Alzheimer's disease and 8 individuals with no cognitive impairment. We identify brain-region- and species-enriched genes and pathways. We reveal molecular principles of human arteriovenous organization, recapitulating a

SUBMITTER: Yang AC 

PROVIDER: S-EPMC9635042 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature