Safety and efficacy of corticosteroids in ARDS patients: a systematic review and meta-analysis of RCT data.

ABSTRACT:

Purpose

Acute respiratory distress syndrome (ARDS) is an acute and critical disease among children and adults, and previous studies have shown that the administration of corticosteroids remains controversial. Therefore, a meta-analysis of randomized controlled trials (RCTs) was performed to evaluate the safety and efficacy of corticosteroids.

Methods

The RCTs investigating the safety and efficacy of corticosteroids in ARDS were searched from electronic databases (Embase, Medline, and the Cochrane Central Register of Controlled Trials). The primary outcome was 28-day mortality. Heterogeneity was assessed using the Chi square test and I² with the inspection level of 0.1 and 50%, respectively.

Results

Fourteen RCTs (n = 1607) were included for analysis. Cortic

SUBMITTER: Chang X 

PROVIDER: S-EPMC9635104 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature