Polygenic scores for low lung function and the future risk of adverse health outcomes.

ABSTRACT:

Aims

Reduced lung function and adverse health outcomes are often observed. This study characterizes genetic susceptibility for reduced lung function and risk of developing a range of adverse health outcomes.

Methods

We studied 27,438 middle-aged adults from the Malmö Diet and Cancer study (MDCS), followed up to 28.8 years. Trait-specific Polygenic scores (PGS) for forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) were constructed for each participant using MDCS genetic data and summary statistics from the latest GWAS of lung function. Linear regression models and cox proportional hazards regression models were used to assess associations between adverse health outcomes and lung function-PGS.

Results

FEV₁-PGS and FVC-PGS were

SUBMITTER: Zaigham S 

PROVIDER: S-EPMC9635172 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature