ITRAQ-based proteomic analysis of Deinococcus radiodurans in response to ¹²C⁶⁺ heavy ion irradiation.

ABSTRACT:

Background

Deinococcus radiodurans (D. radiodurans) is best known for its extreme resistance to diverse environmental stress factors, including ionizing radiation (IR), ultraviolet (UV) irradiation, oxidative stress, and high temperatures. Robust DNA repair system and antioxidant system have been demonstrated to contribute to extreme resistance in D. radiodurans. However, practically all studies on the mechanism underlying D. radiodurans's extraordinary resistance relied on the treated strain during the post-treatment recovery lag phase to identify the key elements involved. The direct gene or protein changes of D. radiodurans after stress have not yet been characterized.

Results

In this study, we performed a proteomics profiling on D. radiodurans right after the heavy ion i

SUBMITTER: Gao Y 

PROVIDER: S-EPMC9635210 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature