Mediating effect of vascular risk factors underlying the link between gestational diabetes and cardiovascular disease.

ABSTRACT:

Background

Women with gestational diabetes (GDM) have an elevated lifetime incidence of cardiovascular disease (CVD), but the basis of this excess risk remains to be established. In this context, we hypothesized that chronic exposure to adverse cardiovascular risk factors may contribute to their elevated risk of CVD. We thus sought to quantify the determinants of CVD risk in women with a history of GDM by performing mediation analyses.

Methods

Women in Ontario, Canada, with a live-birth pregnancy between Jan 1998 and Dec 2017 (n=757,541) were followed for a median of 13.2 years and stratified into the following 4 groups: women with GDM who developed CVD (GDM+/CVD+); women without GDM who developed CVD (GDM-/CVD+); those with GDM but no CVD (GDM+/CVD-); and those with neither

SUBMITTER: Retnakaran R 

PROVIDER: S-EPMC9635213 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature