IgA quantification as a good predictor of the neutralizing antibodies levels after vaccination against SARS-CoV-2.

ABSTRACT:

Background

Vaccination against COVID-19 was implemented very quickly, but the emergence of new variants that can evade the previous acquired immunological protection highlights the importance of understanding the mechanisms involved in the immune response generated after SARS-CoV-2 infection or vaccination.

Objectives

Since most of our knowledge on the humoral immunity generated against SARS-CoV-2 has been obtained from studies with infected patients before vaccination, our goal here was to evaluate seroconversion and its correlation with the titers of neutralizing antibodies (NAbs) in individuals who received the complete initial recommended vaccination schedule with three different vaccines.

Study design

We analyzed serum IgG, IgA and total NAbs against the trimeric

SUBMITTER: Fernandes-Siqueira LO 

PROVIDER: S-EPMC9635250 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature