Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions.

ABSTRACT: Presynaptic metabotropic glutamate receptors (mGluRs) are essential for the control of synaptic transmission. However, how the subsynaptic dynamics of these receptors is controlled and contributes to synaptic signaling remain poorly understood quantitatively. Particularly, since the affinity of individual mGluR subtypes for glutamate differs considerably, the activation of mGluR subtypes critically depends on their precise subsynaptic distribution. Here, using superresolution microscopy and single-molecule tracking, we unravel novel molecular mechanisms that control the nanoscale distribution and mobility of presynaptic mGluRs in hippocampal neurons. We demonstrate that the high-affinity group II receptor mGluR2 localizes diffusely along the axon, and is highly mobile, while the low-affini

SUBMITTER: Bodzeta A 

PROVIDER: S-EPMC9635276 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature