Terminally differentiated osteoclasts organize centrosomes into large clusters for microtubule nucleation and bone resorption.

ABSTRACT: Osteoclasts are highly specialized, multinucleated cells responsible for the selective resorption of the dense, calcified bone matrix. Microtubules (MTs) contribute to the polarization and trafficking events involved in bone resorption by osteoclasts; however, the origin of these elaborate arrays is less clear. Osteoclasts arise through cell fusion of precursor cells. Previous studies have suggested that centrosome MT nucleation is lost during this process, with the nuclear membrane and its surrounding Golgi serving as the major MT organizing centers (MTOCs) in these cells. Here we reveal that precursor cell centrosomes are maintained and functional in the multinucleated osteoclast and interestingly form large MTOC clusters, with the clusters organizing significantly more MTs compared with

SUBMITTER: Philip R 

PROVIDER: S-EPMC9635281 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature