Unique Pakistani gut microbiota highlights population-specific microbiota signatures of type 2 diabetes mellitus.

ABSTRACT: Biogeographic variations in the gut microbiota are pivotal to understanding the global pattern of host-microbiota interactions in prevalent lifestyle-related diseases. Pakistani adults, having an exceptionally high prevalence of type 2 diabetes mellitus (T2D), are one of the most understudied populations in microbiota research to date. The aim of the present study is to examine the gut microbiota across individuals from Pakistan and other populations of non-industrialized and industrialized lifestyles with a focus on T2D. The fecal samples from 94 urban-dwelling Pakistani adults with and without T2D were profiled by bacterial 16S ribosomal RNA gene and fungal internal transcribed spacer (ITS) region amplicon sequencing and eubacterial qPCR, and plasma samples quantified for circulating lev

SUBMITTER: Saleem A 

PROVIDER: S-EPMC9635555 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature