Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans.

ABSTRACT: Multipotent stem and progenitor cells have the capacity to generate a limited array of related cell types. The Caenorhabditis elegans somatic gonadal precursors are multipotent progenitors that generate all 143 cells of the somatic gonad, including complex tissues and specialized signaling cells. To screen for candidate regulators of cell fate and multipotency, we identified transcription factor genes with higher expression in somatic gonadal precursors than in their differentiated sister, the head mesodermal cell. We used RNA interference or genetic mutants to reduce the function of 183 of these genes and examined the worms for defects in the somatic gonadal precursor cell fate or the ability to generate gonadal tissue types. We identify 8 genes that regulate somatic gonadal precursor fat

SUBMITTER: Soukup EM 

PROVIDER: S-EPMC9635636 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature