A TRiP RNAi Screen to Identify Molecules Necessary for Drosophila Photoreceptor Differentiation.

ABSTRACT: Drosophila rhabdomeric terminal photoreceptor differentiation is an extended process taking several days to complete. Following ommatidial patterning by the morphogenetic furrow, photoreceptors are sequentially recruited and specified, and terminal differentiation begins. Key events of terminal differentiation include establishment of apical and basolateral domains, rhabdomere and stalk formation, inter-rhabdomeral space formation, and expression of phototransduction machinery. While many key regulators of these processes have been identified, the complete network of transcription factors to downstream effector molecules necessary for regulating each of these major events remains incomplete. Here we report an RNAi screen to identify additional molecules and cellular pathways required for p

SUBMITTER: Rylee J 

PROVIDER: S-EPMC9635655 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature