Purifying selection enduringly acts on the sequence evolution of highly expressed proteins in Escherichia coli.

ABSTRACT: The evolutionary speed of a protein sequence is constrained by its expression level, with highly expressed proteins evolving relatively slowly. This negative correlation between expression levels and evolutionary rates (known as the E-R anticorrelation) has already been widely observed in past macroevolution between species from bacteria to animals. However, it remains unclear whether this seemingly general law also governs recent evolution, including past and de novo, within a species. However, the advent of genomic sequencing and high-throughput phenotyping, particularly for bacteria, has revealed fundamental gaps between the 2 evolutionary processes and has provided empirical data opposing the possible underlying mechanisms which are widely believed. These conflicts raise questions abou

SUBMITTER: Shibai A 

PROVIDER: S-EPMC9635659 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature