Analyses of mutational patterns induced by formaldehyde and acetaldehyde reveal similarity to a common mutational signature.

ABSTRACT: Formaldehyde and acetaldehyde are reactive small molecules produced endogenously in cells as well as being environmental contaminants. Both of these small aldehydes are classified as human carcinogens, since they are known to damage DNA and exposure is linked to cancer incidence. However, the mutagenic properties of formaldehyde and acetaldehyde remain incompletely understood, at least in part because they are relatively weak mutagens. Here, we use a highly sensitive yeast genetic reporter system featuring controlled generation of long single-stranded DNA regions to show that both small aldehydes induced mutational patterns characterized by predominantly C/G → A/T, C/G → T/A, and T/A → C/G substitutions, each in similar proportions. We observed an excess of C/G → A/T transversions when com

SUBMITTER: Thapa MJ 

PROVIDER: S-EPMC9635668 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature