No robust evidence for an interaction between early-life adversity and protective factors on global and regional brain volumes.

ABSTRACT: Childhood adversity is associated with brain morphology and poor psychological outcomes, and evidence of protective factors counteracting childhood adversity effects on neurobiology is scarce. We examined the interplay of childhood adversity with protective factors in relation to brain morphology in two independent longitudinal cohorts, the Generation R Study (N = 3008) and the Mannheim Study of Children at Risk (MARS) (N = 179). Cumulative exposure to 12 adverse events was assessed across childhood until age 9 years in Generation R and 11 years in MARS. Protective factors (temperament, cognition, self-esteem, maternal sensitivity, friendship quality) were assessed at various time-points during childhood. Global brain volumes and volumes of amygdala, hippocampus, and the anterior cingulate

SUBMITTER: Cortes Hidalgo AP 

PROVIDER: S-EPMC9636055 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature