Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response.

ABSTRACT: This study aims to investigate the role of metal regulatory transcription factor 1 (MTF1)-mediated metal response in cadmium (Cd)-induced cerebellar injury, and to evaluate the antagonistic effects of nano-selenium (Nano-Se) against Cd toxicity. A total of 80 chicks (1 d old, male, Hy-Line Variety White) were randomly allocated to 4 treatment groups for 3 months: the control group (fed with a basic diet, n = 20), the Nano-Se group (basic diet with 1 mg/kg nano-Se 1 mg/kg Nano-Se in basic diet, n = 20), the Nano-Se + Cd group (basic diet with 1 mg/kg Nano-Se and 140 mg/kg CdCl₂, n = 20) and the Cd group (basic diet with 140 mg/kg CdCl₂ , n = 20). The results of the experiment showed that the Purkinje cells were significantly decreased with t

SUBMITTER: Bi SS 

PROVIDER: S-EPMC9636061 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature