Spatial analysis of the glioblastoma proteome reveals specific molecular signatures and markers of survival.

ABSTRACT: Molecular heterogeneity is a key feature of glioblastoma that impedes patient stratification and leads to large discrepancies in mean patient survival. Here, we analyze a cohort of 96 glioblastoma patients with survival ranging from a few months to over 4 years. 46 tumors are analyzed by mass spectrometry-based spatially-resolved proteomics guided by mass spectrometry imaging. Integration of protein expression and clinical information highlights three molecular groups associated with immune, neurogenesis, and tumorigenesis signatures with high intra-tumoral heterogeneity. Furthermore, a set of proteins originating from reference and alternative ORFs is found to be statistically significant based on patient survival times. Among these proteins, a 5-protein signature is associated with survi

SUBMITTER: Duhamel M 

PROVIDER: S-EPMC9636229 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature