Whole-embryonic identification of maternal microchimeric cell types in mouse using single-cell RNA sequencing.

ABSTRACT: Even though the mother and the fetus of placental mammals are immunologically non-self with respect to one other, mutual exchange of small numbers of cells between them is known to occur. Maternal cells entering the fetus, called maternal microchimeric cells (MMc cells), are thought to be involved in different physiological phenomena, such as establishing immune tolerance, tissue repair, and the pathogenesis or deterioration of some inflammatory diseases and congenital malformations. While specific MMc cell types have been reported as associated with these phenomena, the contribution of MMc cells to these different outcomes remains unknown. As one possibility, we hypothesized that different embryos have differing repertoires of MMc cell types, leading to or biasing embryos toward different

SUBMITTER: Fujimoto K 

PROVIDER: S-EPMC9636240 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature