Bioinformatics analysis of the key genes in osteosarcoma metastasis and immune invasion.

ABSTRACT:

Background

This study sought to identify potential key genes for osteosarcoma metastasis and analyze their immune infiltration patterns using bioinformatic methods.

Methods

We obtained transcriptomic data related to osteosarcoma and osteosarcoma with metastasis from the Therapeutically Applicable Research to Generate Effective Treatment (TARGET) and The Gene Expression Omnibus (GEO) databases and identified the differentially expressed genes (DEGs). We also identified potential key genes for osteosarcoma metastasis by a protein-protein interaction network analysis, and we conducted a Gene Ontology (GO) functional annotation analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to identify the core genes for prognosis, immune cell infiltration, and d

SUBMITTER: Liang J 

PROVIDER: S-EPMC9636461 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature