Microbial and host factors contribute to bloodstream infection in a pediatric acute lymphocytic leukemia mouse model.

ABSTRACT:

Background

Hematological malignancies are the most common cancers in the pediatric population, and T-cell acute lymphocytic leukemia (T-ALL) is the most common hematological malignancy in children. Bloodstream infection (BSI) is a commonly occurring complication in leukemia due to underlying conditions and therapy-induced neutropenia. Several studies identified the gut microbiome as a major source of BSI due to bacterial translocation. This study aimed to investigate changes in the intestinal and fecal microbiome, and their roles in the pathophysiology of BSI in a pediatric T-ALL mouse model using high-throughput shotgun metagenomics sequencing, and metabolomics.

Results

Our results show that BSI in ALL is characterized by an increase of a mucin degrading bacterium (Akker

SUBMITTER: Song Y 

PROVIDER: S-EPMC9636473 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature