Ontology highlight
ABSTRACT:
SUBMITTER: Park JS
PROVIDER: S-EPMC9636537 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Park Joon Sung JS Choi Jungyuen J Cao Longxing L Mohanty Jyotidarsini J Suzuki Yoshihisa Y Park Andy A Baker David D Schlessinger Joseph J Lee Sangwon S
Cell reports 20221001 4
Cellular signaling by fibroblast growth factor receptors (FGFRs) is a highly regulated process mediated by specific interactions between distinct subsets of fibroblast growth factor (FGF) ligands and two FGFR isoforms generated by alternative splicing: an epithelial b- and mesenchymal c-isoforms. Here, we investigate the properties of a mini-protein, mb7, developed by an in silico design strategy to bind to the ligand-binding region of FGFR2. We describe structural, biophysical, and cellular ana ...[more]