Socioeconomic and race/ethnic differences in immunosenescence: Evidence from the Health and Retirement Study.

ABSTRACT:

Background

The COVID-19 pandemic has highlighted the urgent need to understand variation in immunosenescence at the population-level. Thus far, population patterns of immunosenescence have not well described.

Methods

We characterized measures of immunosenescence from the 2016 Venous Blood Study from the nationally representative U.S Health and Retirement Study (HRS) of individuals ages 50 years and older.

Results

Median values of the CD8+:CD4+, EMRA:Naïve CD4+ and EMRA:Naïve CD8+ ratios were higher among older participants and were lower in those with additional educational attainment. Generally, minoritized race and ethnic groups had immune markers suggestive of a more aged immune profile: Hispanics had a CD8+:CD4+ median value of 0.37 (95 % CI: 0.35, 0.39) compared

SUBMITTER: Noppert GA 

PROVIDER: S-EPMC9636606 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature