Identification of long non-coding RNA using single nucleotide epimutation analysis: a novel gene discovery approach.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) are involved in a variety of mechanisms related to tumorigenesis by functioning as oncogenes or tumor-suppressors or even harboring oncogenic and tumor-suppressing effects; representing a new class of cancer biomarkers and therapeutic targets. It is predicted that more than 35,000 ncRNA especially lncRNA are positioned at the intergenic regions of the human genome. Emerging research indicates that one of the key pathways controlling lncRNA expression and tissue specificity is epigenetic regulation.

Methods

In the current article, a novel approach for lncRNA discovery based on the intergenic position of most lncRNAs and a single CpG site methylation level representing epigenetic characteristics has been suggested.

Results

Using

SUBMITTER: Kerachian MA 

PROVIDER: S-EPMC9636742 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature