Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway

ABSTRACT:

Background

Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored.

Methods

Aβ-induced neurite and mitochondrial damage assays were used to evaluate Aβ toxicity and the neuroprotective efficacy of a natural compound salidroside (SAL). The 5×FAD transgenic mouse model of AD was used to study the neuroprotective function of SAL. To verify the direct target of SAL, we used surface plasmon resonance and cellular thermal shift assays to analyze the drug-protein interaction.

Results

SAL ameliorates Aβ-mediated neurite damage in cell culture. We further reveal that SAL represses mitochondrial damage in neurites by promoting mitophagy and maintaining mitochondrial homeos

SUBMITTER: Yao Y 

PROVIDER: S-EPMC9636768 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature