Ontology highlight
ABSTRACT:
SUBMITTER: Linville RM
PROVIDER: S-EPMC9636829 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Linville Raleigh M RM Sklar Matthew B MB Grifno Gabrielle N GN Nerenberg Renée F RF Zhou Justin J Ye Robert R DeStefano Jackson G JG Guo Zhaobin Z Jha Ria R Jamieson John J JJ Zhao Nan N Searson Peter C PC
Fluids and barriers of the CNS 20221105 1
The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport, and express specialized transporter systems which regulate transcellular transport. However, existing in vitro models of the BBB display variable accuracy across a wide range of characteristics including gene/protein expression and barrier function. Here, we use an isogenic family of fluor ...[more]