Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.

ABSTRACT: Establishing preclinical models of Alzheimer's disease that predict clinical outcomes remains a critically important, yet to date not fully realized, goal. Models derived from human cells offer considerable advantages over non-human models, including the potential to reflect some of the inter-individual differences that are apparent in patients. Here we report an approach using induced pluripotent stem cell-derived cortical neurons from people with early symptomatic Alzheimer's disease where we sought a match between individual disease characteristics in the cells with analogous characteristics in the people from whom they were derived. We show that the response to amyloid-β burden in life, as measured by cognitive decline and brain activity levels, varies between individuals and th

SUBMITTER: Ng B 

PROVIDER: S-EPMC9636855 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature