A model of autonomous interactions between hippocampus and neocortex driving sleep-dependent memory consolidation.

ABSTRACT: How do we build up our knowledge of the world over time? Many theories of memory formation and consolidation have posited that the hippocampus stores new information, then "teaches" this information to the neocortex over time, especially during sleep. But it is unclear, mechanistically, how this actually works-How are these systems able to interact during periods with virtually no environmental input to accomplish useful learning and shifts in representation? We provide a framework for thinking about this question, with neural network model simulations serving as demonstrations. The model is composed of hippocampus and neocortical areas, which replay memories and interact with one another completely autonomously during simulated sleep. Oscillations are leveraged to support error-driven lea

SUBMITTER: Singh D 

PROVIDER: S-EPMC9636926 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature