The influence of molecular design on structure-property relationships of a supramolecular polymer prodrug.

ABSTRACT: Supramolecular self-assemblies of hydrophilic macromolecules functionalized with hydrophobic, structure-directing components have long been used for drug delivery. In these systems, loading of poorly soluble compounds is typically achieved through physical encapsulation during or after formation of the supramolecular assembly, resulting in low encapsulation efficiencies and limited control over release kinetics, which are predominately governed by diffusion and carrier degradation. To overcome these limitations, amphiphilic prodrugs that leverage a hydrophobic drug as both the therapeutic and structure-directing component can be used to create supramolecular materials with higher loading and controlled-release kinetics using biodegradable or enzymatically cleavable linkers. Here, we report

SUBMITTER: DeFrates KG 

PROVIDER: S-EPMC9636931 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature