A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults.

ABSTRACT: Aging is associated with gradual changes in cognition, yet some individuals exhibit protection against age-related cognitive decline. The topological characteristics of brain networks that promote protection against cognitive decline in aging are unknown. Here, we investigated whether the robustness and resilience of brain networks, queried via the delineation of the brain's core network structure, relate to age and cognitive performance in a cross-sectional dataset of healthy middle- and old-aged adults (n = 478, ages 40 to 90 y). First, we decomposed each subject's functional brain network using k-shell decomposition and found that age was negatively associated with robust core network structures. Next, we perturbed these networks, via attack simulations, and found that res

SUBMITTER: Stanford WC 

PROVIDER: S-EPMC9636938 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature