Electrical signaling in cochlear efferents is driven by an intrinsic neuronal oscillator.

ABSTRACT: Efferent neurons are believed to play essential roles in maintaining auditory function. The lateral olivocochlear (LOC) neurons-which project from the brainstem to the inner ear, where they release multiple transmitters including peptides, catecholamines, and acetylcholine-are the most numerous yet least understood elements of efferent control of the cochlea. Using in vitro calcium imaging and patch-clamp recordings, we found that LOC neurons in juvenile and young adult mice exhibited extremely slow waves of activity (∼0.1 Hz). These seconds-long bursts of Na⁺ spikes were driven by an intrinsic oscillator dependent on L-type Ca²⁺ channels and were not observed in prehearing mice, suggesting an age-dependent mechanism underlying the intrinsic oscillator. Using optogene

SUBMITTER: Hong H 

PROVIDER: S-EPMC9636947 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature