High prevalence of SARS-CoV-2 antibodies in pregnant women, after the second wave of infections in the inner city of Johannesburg, Gauteng Province, South Africa.

ABSTRACT:

Objectives

After South Africa's second wave of COVID-19, this study estimated the SARS-CoV-2 seroprevalence among pregnant women in inner-city Johannesburg, South Africa.

Methods

In this cross-sectional survey, 500 non-COVID-19-vaccinated pregnant women (aged ≥12 years) were enrolled, and demographic and clinical data were collected. Serum samples were tested using the Wantai SARS-CoV-2 spike Ab ELISA and Roche Elecsys® Anti-SARS-CoV-2 nucleocapsid antibody assays. Seropositivity was defined as SARS-CoV-2 antibodies on either (primary) or both (secondary) assays. Univariate Poisson regression assessed risk factors associated with seropositivity.

Results

Median age was 27.4 years and HIV prevalence 26.7%. SARS-CoV-2 seroprevalence was 64.0% (95% CI:59.6%-68.2%) on the

SUBMITTER: S S 

PROVIDER: S-EPMC9637015 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature