Maternal Transfer and Long-Term Population Effects of PCBs in Baltic Grey Seals Using a New Toxicokinetic-Toxicodynamic Population Model.

ABSTRACT: Empirical evidence has shown that historical exposure of polychlorinated biphenyls (PCBs) to Baltic grey seals not only severely affected individual fitness, but also population growth rates and most likely caused the retarded recovery rate of the depleted population for decades. We constructed a new model which we term a toxicokinetic-toxicodynamic (TKTD) population model to quantify these effects. The toxicokinetic sub-model describes in detail the bioaccumulation, elimination and vertical transfer from mother to offspring of PCBs and is linked to a toxicodynamic model for estimation of PCB-related damage, hazard and stress impacts on fertility and survival rates. Both sub-models were linked to a Leslie matrix population model to calculate changes in population growth rate and age struct

SUBMITTER: Mauritsson K 

PROVIDER: S-EPMC9637078 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature