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Economic interests cloud hazard reductions in the European regulation of substances of very high concern.

ABSTRACT: Here we investigate how the conflicts between hazard reduction and economic interests have shaped the regulation of substances of very high concern (SVHCs) under the Authorization program of the European chemical regulation Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH). Since regulation starts with listing SVHCs on the Candidate List, we analyze the relative importance of toxicological properties, economic motivations, and available scientific knowledge on the probability of inclusion on the Candidate List. We find that the most important factor in whether a substance is listed is whether it is being produced in, or imported into, the European Economic Area (EEA), with the regulators less likely to place a substance on the list if it is currently being produced or imported in the EEA. This evidence suggests that regulators have listed chemicals of secondary importance leading to lesser than anticipated hazard reductions, either because production and imports had already ceased before the listing, or because the compound has never been produced or imported in the EEA at all.

SUBMITTER: Coria J

PROVIDER: S-EPMC9637112 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Economic interests cloud hazard reductions in the European regulation of substances of very high concern.

Coria Jessica J Kristiansson Erik E Gustavsson Mikael M

Nature communications 20221105 1

Here we investigate how the conflicts between hazard reduction and economic interests have shaped the regulation of substances of very high concern (SVHCs) under the Authorization program of the European chemical regulation Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH). Since regulation starts with listing SVHCs on the Candidate List, we analyze the relative importance of toxicological properties, economic motivations, and available scientific knowledge on the pro ...[more]

PMID: 36335108

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Project description:BackgroundConsumers have the right to inquire whether a consumer article contains substances of very high concern ('SVHC right to know'). This communication tool is designed to stimulate suppliers to substitute such ingredients. A survey among 1321 consumers with high motivation and interest in harmful substances in everyday products was conducted to understand the acceptance of this 'right to know' among consumers.ResultsOnly one out of seven survey participants stated to be well informed about the 'SVHC right to know' with nearly all of them having good self-reported chemical knowledge. Three quarters of the participants who are not working with chemicals or REACH at their workplace have never heard about the 'SVHC right to know'. Every second participant declared their interest to search for more information about an SVHC in a certain article, but, in fact, not more than 4% of all participants inquired for SVHCs with various methods. Only 1% would buy an SVHC-containing article with no strings attached. While detailed comments by some survey participants showed a high level of understanding of the issue, many respondents were not sure what the SVHC information means for their daily life. They declared that they would inform themselves, reduce the use of the article with SVHCs, circulate this information, or throw such an article into the garbage. Most study participants suggested improvements of the 'SVHC right to know'. The preferred suggestions were a ban of SVHCs, easily understandable information on the packaging, full ingredient declaration on the articles, or no need to inquire for every single item, while smartphone applications for SVHC requests were the least popular suggestion in all age groups.ConclusionsVarious reasons could be identified why most consumers-even these motivated and interested ones-do not use the 'SVHC right to know'. This allowed developing recommendations for improving the effectiveness of this communication instrument on the way to the gradual elimination of SVHCs in consumer articles.

Project description:Endocrine-disrupting substances (EDS) may have certain biological effects including delayed effects, multigenerational effects, and may display nonmonotonic dose-response (NMDR) relationships that require careful consideration when determining environmental hazards. Endocrine disrupting substances can have specific and profound effects when exposure occurs during sensitive windows of the life cycle (development, reproduction). This creates the potential for delayed effects that manifest when exposure has ceased, possibly in a different life stage. This potential underscores the need for testing in appropriate (sensitive) life stages and full life cycle designs. Such tests are available in the Organisation for Economic Co-operation and Development (OECD) tool box and should be used to derive endpoints that can be considered protective of all life stages. Similarly, the potential for effects to be manifest in subsequent generations (multigenerational effects) has also been raised as a potential issue in the derivation of appropriate endpoints for EDS. However, multigenerational studies showing increasing sensitivity of successive generations are uncommon. Indeed this is reflected in the design of new higher tier tests to assess endocrine active substances (EAS) that move to extended one-generation designs and away from multi-generational studies. The occurrence of NMDRs is also considered a limiting factor for reliable risk assessment of EDS. Evidence to date indicates NMDRs are more prevalent in in vitro and mechanistic data, not often translating to adverse apical endpoints that would be used in risk assessment. A series of steps to evaluate NMDRs in the context of endocrine hazard and risk assessment procedures is presented. If careful consideration of delayed, multigenerational effects and NMDRs is made, it is feasible to assess environmental endocrine hazards and derive robust apical endpoints for risk assessment procedures ensuring a high level of environmental protection. Integr Environ Assess Manag 2017;13:293-301. © 2016 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

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Economic interests cloud hazard reductions in the European regulation of substances of very high concern.

Publications

Economic interests cloud hazard reductions in the European regulation of substances of very high concern.

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