Pulmonary function in school-age children following intravitreal injection of bevacizumab for retinopathy of prematurity.

ABSTRACT: The effect of anti-vascular endothelial growth factor on neonatal lung development was inconclusive. To evaluate pulmonary function in school-age children who have received intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP), this study included 118 school-aged children who were grouped into three groups: full-term control children (group 1), preterm children who had not received IVB treatment (group 2) and preterm children with ROP who had received IVB treatment (group 3). Pulmonary function was measured by spirometry and impulse oscillometry. Pulmonary function was significantly better in group 1 than in groups 2 and 3 (all p < 0.05 in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV₁), forced expiratory flow between 25 and 75% of FVC (FEF

SUBMITTER: Huang CY 

PROVIDER: S-EPMC9637204 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature