Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway.

ABSTRACT: Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found that patients with high score of psychological depression were correlated with tumor invasion and metastasis. We found focal adhesion kinase (FAK) was increased in cancer patients with metastatic features and high score of depression. FAK knockdown completely blocked depression-promoted tumor invasion in orthotopic transplantation tumors. In Hi-myc mice and a murine model of depression, sympathetic activation was detected in the prostate tissue. Further we showed that FAK activation was dependent on a cAMP-PKA signaling pathway. Our results demonstrated that the activation o

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC9637327 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature